Insulintruth’s Weblog

Living with Hypoglycemia Unawareness & some thoughts about insulin

Posts Tagged ‘Tyrosine Kinase Inhibitor’

Type 1 Cure Discovered!

Posted by insulintruth on December 12, 2008

Type 1 Cure Discovered!

OK, I’ve followed up on Gleevec and its effects in causing remission of type 1 diabetes. It works by inhibiting the action of certain members of a class of enzymes called tyrosine kinases which transfer phosphates from donor to receptor cells (phosphorylation). There are twenty classes of these kinases and the 2nd class is involved with insulin production. Inhibition of one of the tyrosine kinase receptors in this group prevents cellular apoptosis, or programmed cell death, and in this case revives the function of the insulin-producing beta cells. A study came out ten years ago showing that beta cells are not actually dead, but rather suppressed, and this falls right in line with the implications of that study, that they could be reactivated. Now using Gleevec for this purpose is overkill, beacuse it contains mulitple TK inhibitors and only one is necessary for the remission of Type 1 diabetes. Also, it’s expensive as hell, looking online, it seems to average about $90. per pill and needs to be taken for about 10 weeks for lomg term remission.Check the blogroll for links to related articles.

Posted in Diabetes, Hypoglycemia Unawareness, new findings | Tagged: , , | 2 Comments »