Dear Friends, I have to report that after I sent Children With Diabetes (see blogroll) a message asking them to comment on the Imatinib/PDGF inhibition effects, they pointed out that the paper concerning Imatinib was referring to Type 2, not Type 1 subjects. This is how it was expressed in the study abstract: “All patients had been diagnosed as diabetic at least 10 years before CML onset. Three patients were using insulin, and four patients were taking oral antidiabetic drugs for glycemic control.”
I thought it meant three Type 1s and four Type 2s, but apparently all were Type 2s. The research is still valid, however, and may have effects on Type 1s, if it turns out the beta cells are only suppressed, not completely dead, as was indicated by the report I mentioned earlier done in the late 90s. If anyone can turn it up, I’d really like to have the citation. Also the effects of the PDGF inhibitor were faster, this was the ten-day effect as opposed to the ten-week effect of Imatinib I referred to earlier, so again this may be effective in restoring function for Type 1 beta cells. Hope I didn’t get anyone’s hopes too high up as mine were for a while, but stay positive!
